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The Cannabis Review® | Terpenes

Terpenes are molecules partially responsible for the aroma and taste of cannabis. They are naturally present in a number of fruits, spices, herbs and other vegetation, and research shows they have many potential medical applications. The Cannabis Review® | Terpenes is a collection of scientific studies that identify conditions treated by terpenes, by what mechanism, the magnitude of that effect, and the amount of the terpene used in the study.

Grade

This is the measurement of the nature and methodology of the scientific study.

Double-blind, placebo controlled clinical study
Open clinical trial study; no control group and no blinded clinical trial
Non-human subject research on isolated cannabis compounds
Non-human subject research on cannabis compound in a mixture

Magnitude of Effect

This identifies how effective the biological activity of the cannabinoid was treating the condition.

majorBiological activity has a major effect on the condition
moderateBiological activity has a moderate effect on the condition
minorBiological activity has a minor effect on the condition

Primary Studies

The following are scientific studies that have shown the effectiveness of terpenes treating specific conditions. Study names are linked to the studies, click to view.

TerpenesCondition treatedEffectAmount usedStudyGrade
Borneol (Also found in heterotheca, artemisia, callicarpa, dipterocarpaceae, blumea balsamifera & kaempferia galanga)CancerAnticancer (major)N/ANatural Borneol, a Monoterpenoid Compound, Potentiates Selenocystine-Induced Apoptosis in Human Hepatocellular Carcinoma Cells by Enhancement of Cellular Uptake and Activation of ROS-Mediated DNA Damage
N/ANatural Borneol, a Monoterpenoid Compound, Potentiates Selenocystine-Induced Apoptosis in Human Hepatocellular Carcinoma Cells by Enhancement of Cellular Uptake and Activation of ROS-Mediated DNA Damage
N/ANatural borneol enhances bisdemethoxycurcumin-induced cell cycle arrest in the G2/M phase through up-regulation of intracellular ROS in HepG2 cells
Fungal contaminationAntifungal (major)N/ABorneol-grafted cellulose for antifungal adhesion and fungal growth inhibition
InflammationAntiinflammatory (major)N/AAnalgesic and Anti-inflammation Effect of Borneol
Microbiological contaminationAntimicrobial (moderate)4.91% of mixtureChemical Composition and Antimicrobial Activity of Essential Oil of Thyme (Thymusvulgaris) from Eastern Morocco
Oral mucositisAntiinflammatory (moderate)1.2% of mixture,
2.4% of mixture
Anti-inflammatory and healing action of oral gel containing borneol monoterpene in chemotherapy-induced mucositis in rats ( Rattus norvegicus )
Oral submucous fibrosisAntifibrosis (moderate)18.75 to 300 μg/mLInfluence of borneol on primary mice oral fibroblasts: a penetration enhancer may be used in oral submucous fibrosis
PainAnalgesics (major)N/AA clinical and mechanistic study of topical borneol‐induced analgesia
Tension of the blood vessel wallsVasorelaxant (moderate)N/AInvestigation of Mechanisms Involved in (−)-Borneol-Induced Vasorelaxant Response on Rat Thoracic Aorta

Secondary Materials

The following are study reviews and other materials of note

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