The Cannabis Review® | Effects :: MCR Labs

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The Cannabis Review® | Effects

Cannabis has been shown to have many beneficial effects on users. The Cannabis Review® | Effects is a collection of scientific studies that identifies the molecules, found in cannabis, that have specific effects on users, the magnitude of that effect, and the amount of molecule used in the study.

Grade

This is the measurement of the nature and methodology of the scientific study.

	Double-blind, placebo controlled clinical study
	Open clinical trial study; no control group and no blinded clinical trial
	Non-human subject research on isolated cannabis compounds
	Non-human subject research on cannabis compound in a mixture

Magnitude of Effect

This identifies how effective the biological activity of the cannabinoid was treating the condition.

major	Biological activity has a major effect on the condition
moderate	Biological activity has a moderate effect on the condition
minor	Biological activity has a minor effect on the condition

Primary Studies

The following scientific studies establish the potential effectiveness for treating specific conditions using molecules found in cannabis. The study names link to the full studies; click to view.

Effect	Magnitude	Cannabinoid/ Terpene	Condition treated	Amount used	Study
Analgesic	major	Borneol	Pain	N/A	A clinical and mechanistic study of topical borneol‐induced analgesia
	major	THC (Tetrahydrocannabinol)	Neuropathic Pain	25mg	Smoked cannabis for chronic neuropathic pain: a randomized controlled trial
	minor	Myrcene	Hyperalgesia	N/A	Myrcene mimics the peripheral analgesic activity of lemongrass tea.
		THC (Tetrahydrocannabinol)	Multiple sclerosis	10mg	Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial.
		THC (Tetrahydrocannabinol)	Pain	5mg	Lack of analgesic efficacy of oral delta-9-tetrahydrocannabinol in postoperative pain
	moderate	CBD (Cannabidiol)	Central neuropathic pain	25mg/mL	Oromucosal Δ9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: An uncontrolled, open-label, 2-year extension trial
			Multiple sclerosis	2.5mg	Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis
				2-10 inhalations	A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis
				2-10 inhalations	A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis
			Pain	2.5mg	Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 ‘N of 1’ studies

Secondary Materials

The following are study reviews and other materials of note

Effect	Magnitude	Cannabinoid/ Terpene	Condition treated	Study
Analgesic	moderate	CBD (Cannabidiol)	Multiple sclerosis	Randomised controlled trial of cannabis based medicinal extracts (CBME) in central neuropathic pain due to multiple sclerosis
		Caryophyllene	Pain	β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties
		Caryophyllene oxide	Pain	β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties
		THC (Tetrahydrocannabinol)	Multiple sclerosis	Randomised controlled trial of cannabis based medicinal extracts (CBME) in central neuropathic pain due to multiple sclerosis
Anticancer	major	Limonene	Cancer	Cancer chemoprevention and therapy by monoterpenes
	moderate	CBC (Cannabichromene)	Cancer	The endocannabinoid system and cancer: therapeutic implication
		CBD (Cannabidiol)	Cancer	Cannabidiol as potential anticancer drug
		Caryophyllene	Cancer	β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties
		Caryophyllene oxide	Cancer	β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties
Antidepressant	minor	CBC (Cannabichromene)	Depression	Review Article: Sleep, Pain and Cannabis

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