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The Cannabis Review® | Conditions

Cannabis has been shown to have many potential medical applications. The Cannabis Review® | Conditions is a collection of scientific studies that identify the molecules, found in cannabis, that treat specific conditions, by what effect, the magnitude of that effect, and the amount of molecule used in the study.

Grade

This is the measurement of the nature and methodology of the scientific study.

Double-blind, placebo controlled clinical study
Open clinical trial study; no control group and no blinded clinical trial
Non-human subject research on isolated cannabis compounds
Non-human subject research on cannabis compound in a mixture

Magnitude of Effect

This identifies how effective the biological activity of the cannabinoid was treating the condition.

majorBiological activity has a major effect on the condition
moderateBiological activity has a moderate effect on the condition
minorBiological activity has a minor effect on the condition

Primary Studies

The following are scientific studies that have shown the effectiveness of condition treating specific conditions. Study names are linked to the studies, click to view.

Condition treatedCannabinoid/ TerpeneEffectAmount usedStudyGrade
AD-related NeuroinflammationCBD (Cannabidiol)Antiinflammatory (major)2.5 or 10mg/kgCannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression
ADHDTHC (Tetrahydrocannabinol)Improves behaviour (moderate)71ng/mLCannabis improves symptoms of ADHD
Neuroprotectant (moderate)N/AOral Δ9-Tetrahydrocannabinol Improved Refractory Gilles de la Tourette Syndrome in an Adolescent by Increasing Intracortical Inhibition: A Case Report
ALSCBN (Cannabinol)5mg/kgCannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival
THC (Tetrahydrocannabinol)N/AThe CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset
AcneTHCV (Tetrahydrocannabivarin)Anti-acne (major)N/ADifferential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment
Acute Lung InjuryCBD (Cannabidiol)Antiinflammatory (moderate)20mg/kgCannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: Role for the adenosine A2A receptor
EucalyptolAntiinflammatory (major)100mg/kg,
200mg/kg,
400mg/kg
Eucalyptol suppresses matrix metalloproteinase-9 expression through an extracellular signal-regulated kinase-dependent nuclear factor-kappa B pathway to exert anti-inflammatory effects in an acute lung inflammation model
Acute PancreatitisCBD (Cannabidiol)0.5mg/kgAnti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice
Acute Psychosocial StressTHC (Tetrahydrocannabinol)Anxiolytic (moderate)7.5mg,
12.5mg
Dose-related effects of delta-9-THC on emotional responses to acute psychosocial stress

Secondary Materials

The following are study reviews and other materials of note

Condition treatedCannabinoid/ TerpeneEffectStudy
ALSCBN (Cannabinol)Neuroprotective (moderate)Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?
AnorexiaTHC (Tetrahydrocannabinol)Stimulate appetite (moderate)The cancer cachexia syndrome
BipolarNeuroprotective (moderate)Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential
Bone DiseasesCBD (Cannabidiol)Stimulate Bone Growth (moderate)Edible Marijuana: A New Frontier in the Culinary World
CBN (Cannabinol)Stimulate Bone Growth (minor)Role of cannabinoids in the regulation of bone remodeling
THC (Tetrahydrocannabinol)Stimulate Bone Growth (moderate)Role of cannabinoids in the regulation of bone remodeling
THCV (Tetrahydrocannabivarin)Bone Stimulant (moderate)Role of cannabinoids in the regulation of bone remodeling
CancerCaryophylleneAnticancer (moderate)β-caryophyllene and β-caryophyllene oxide—natural compounds of anticancer and analgesic properties
Caryophyllene oxideβ-caryophyllene and β-caryophyllene oxide—natural compounds of anticancer and analgesic properties
LimoneneAnticancer (major)Cancer chemoprevention and therapy by monoterpenes

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